Core Drug Substances

Thymosin beta 4

Thymosin beta 4 is a small protein consisting of 43 amino acids present in almost all tissues and body fluids in vivo. Initially, thymosin beta 4 was found to play a key role in binding actin to promote cell migration. Since then, multiple mechanisms of action have been described that explain its role in healing dermal, ocular, heart, and nervous system injuries as well as in reducing fibrosis and scarring in many organs. It acts to reduce inflammation and apoptosis and protects cells and tissues. At the molecular level, it enhances the stability of hypoxia-inducible transcription factor (HIF) to promote the expression of Vascular Endothelial Cell Growth Factor (VEGF), thereby increasing angiogenesis. It also induces the expression of proteins such as laminin-5 and plasminogen activator inhibitor-1, and promotes hair growth. Based on these multiple mechanisms of action, it is not unexpected that it plays an important developmental role in the formation of the nervous system, the cardiovascular system, and the formation of teeth.

Disufenton Sodium

Disufenton Sodium is a small molecule that has anti-inflammatory, antioxidant, and cellular death regulatoryproperties. Disufenton Sodium inhibits (1) stabilization and activation of hypoxia-inducible transcription factor 1α (HIF-1α) due to hypoxia and (2) inhibition of expression of activated TGF-β receptors in astrocytes. It affects the regulation of apoptosis, proliferation, migration, and blood vessel formation, and inhibits tumor growth.